Tissue Engineering in Urethral Reconstruction

Vasileios P. Simaioforidis, Wouter F. Feitz

Abstract


Tissue engineering is an integral part of regenerative medicine. It is based on principle of the use of biomaterials in the form of scaffolds and the transportation or seeding transplantation of cells under certain circumstances. These applications aim at the management of pathologic conditions where available tissue for reconstruction is inadequate and they cannot be repaired by classical surgical techniques. In the urological field, patients of all ages need urethral reconstruction, from hypospadias to urethral strictures. In this review the preclinical and clinical evidence regarding urethral tissue engineering is presented.

Εφαρμογές της Μηχανικής των Ιστών στη χειρουργική της ουρήθρας
Η μηχανική των ιστών αποτελεί αναπόσπαστο μέρος της αναγεννητικής ιατρικής. Βασίζεται στην αρχή της χρησιμοποίησης βιοϋλικών στην αντικατάσταση ιστών μέσω της κατασκευής ικριωμάτων και της υπό προϋποθέσεις μεταφοράς κυττάρων σε αυτά. Οι εφαρμογές αυτές αποσκοπούν στην αντιμετώπιση παθολογικών καταστάσεων, στις οποίες ο διαθέσιμος για ανακατασκευή ιστός είναι ανεπαρκής και δεν μπορούν να αντιμετωπιστούν με τις κλασικές χειρουργικές τεχνικές. Στο πεδίο της Ουρολογίας, ασθενείς από όλο το ηλικιακό φάσμα εμφανίζουν την ανάγκη χειρουργικής επέμβασης ανακατασκευής της ουρήθρας, όπως στην περίπτωση υποσπαδία ή ουρηθρικών στενωμάτων. Στην ανασκόπηση αυτή παρουσιάζονται οι εφαρμογές της μηχανικής των ιστών στην αντικατάσταση τμήματος της ουρήθρας σε προκλινικό και κλινικό επίπεδο.


Keywords


Urethra; tissue engineering; biomaterials; scaffolds;ουρήθρα; μηχανική ιστών; βιοϋλικά; ικριώματα

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References


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DOI: http://dx.doi.org/10.19264/hj.v26i2.59