Serenoa Repens in the hands of the modern urologist

Eleftherios Teperikidis, Benjamin Polatidis


Background: Benign Prostatic Hyperplasia (BPH) is a non-malignant enlargement of the prostate gland that affects around 50% of men between the ages of 50 and 60 years old. The application of Serenoa Repens in the treatment of the symptoms of stage I & II BPH is a therapeutic option that is present in the urologist’s agenta for nearly three decades. The purpose of this work is the complete evaluation of existing literature on Serenoa Repens (in-vitro experiments, clinical trials and institutional monographs), summing up clinical trial references in an appendix and raising the necessary issues as far as raw material quality is concerned, providing a good point of reference to the contemporary urologist

Methods: A complete review of the available literature on the effect of the lipidosterolic extract of Serenoa Repens in Benign Prostatic Hyperplasia was conducted. Studies were collected via, and an analytical appendix was formed, providing the full spectrum of available data.

Results: There are contradictions in the available literature, especially in between the results of 1984 to 2014 clinical trials and the available monographs. Contemporary clinical trial publications don’t make any reference to the specifications prescribed by European Pharmacopoieia, which are the only quality markers available.

Conclusion: Future research should focus on and take into account the specifications available in European Pharmacopoieia concerning the content and method of production, providing thorough quantitative analysis of the contents of the extract used in trials.


Serenoa Repens; Saw Palmetto; Benign Prostatic Hyperplasia

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